Vitamin B12 Deficiency: What are the consequences?

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Publications on vitamin B12 and Dementia 

  1. Wilson J, Langman MJ. Relation of sub-acute combined degeneration of the cord to vitamin B 12 deficiency. Nature. 1966 Nov 19;212(5064):787-9

  2. Oxnard CE, Smith WT. Neurological degeneration and reduced serum vitamin B12-levels in captive monkeys. Nature. 1966 Apr 30;210(5035):507-9.

  3. Green R, Van Tonder SV, Oettle GJ, Cole G, Metz J. Neurological changes in fruit bats deficient in vitamin B12. Nature. 1975 Mar 13;254(5496):148-50.

  4. Zucker DK, Livingston RL, Nakra R, Clayton PJ. B12 deficiency and psychiatric disorders: case report and literature review. Biol Psychiatry. 1981 Feb;16(2):197-205. Review

  5. Weber GA, Sloan P, Davies D. Nutritionally induced peripheral neuropathies. Clin Podiatr Med Surg. 1990 Jan;7(1):107-28. Review

  6. Tangney CC, Aggarwal NT, Li H, Wilson RS, Decarli C, Evans DA, Morris MC. Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination. Neurology. 2011 Sep 27;77(13):1276-82. Erratum in: Neurology. 2011 Nov 8;77(19):1773.

  7. Skarupski KA, Tangney C, Li H, Ouyang B, Evans DA, Morris MC. Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. Am J Clin Nutr. 2010 Aug;92(2):330-5. Epub 2010 Jun 2.

  8. Tangney CC, Tang Y, Evans DA, Morris MC. Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. Neurology. 2009 Jan 27;72(4):361-7.

  9. Morris MC, Schneider JA, Tangney CC. Thoughts on B-vitamins and dementia. J Alzheimers Dis. 2006 Aug;9(4):429-33. Review.

  10. Morris MC, Evans DA, Bienias JL, Tangney CC, Hebert LE, Scherr PA, Schneider JA. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol. 2005 Apr;62(4):641-5

  11. Moore E, Mander A, Ames D, Carne R, Sanders K, Watters D Cognitive impairment and vitamin B12: a review. Int Psychogeriatr. 2012 Jan 6:1-16. [Epub ahead of print]

  12. McCaddon, A. and Kelly, C.L. Familial Alzheimer's disease and vitamin B12 deficiency. Age and Ageing, Vol. 23, July 1994, pp. 334-37

  13. Wang, H-X, et al. Vitamin B12 and folate in relation to the development of Alzheimer's disease. Neurology, Vol. 56, No. 9, May 8, 2001, pp. 1188-94

  14. Miller, Joshua W. Vitamin B12 deficiency, tumor necrosis factor-alpha and epidermal growth factor: a novel function of vitamin B12? Nutrition Reviews, Vol. 60, May 2002, pp. 142-51

  15. Eussen, S. J. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. The American Journal of Clinical Nutrition, Vol. 84, August 2006, pp. 361-70

Further Information on Dementia

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