Vitamin B12 Deficiency: What are the consequences?

  Home Nutrition Brain Health Energy Treatment Contact  

 
   

Scientific Publications on the Anti-inflammatory Properties of Vitamin B12 

Vitamin B12 and Nitric Oxide

  1. Broderick, K.E., Singh, V., Zhuang, S., Kambo, A., Chen, J.C., Sharma, V.S., Pilz, R.B., Boss, G.R. 2005 Nitric oxide scavenging by the cobalamin precursor cobinamide. J Biol.Chem. 280, 8678-8685.

  2. Gerth, K., Ehring, T., Braendle, M., Schelling, P. 2006 Nitric oxide scavenging by hydroxoxcobalamin may account for its hemodynamic profile. Clin Toxicol, 44. Suppl 1:29-36

  3. Roncaroli, F., van Eldik, R. 2006 Mechanistic analysis of reductive nitrosylation on water-soluble cobalt(III)-porphryins. J. Am Chem Soc. 128, 8042-53.

  4. Sharma, V.S., Pilz, R.B., Boss, G.R. and Magde, D. 2003 Reactions of nitric oxide with vitamin B12 and its precursor, cobinamide. Biochem, 29, 8900-8

  5. Weinberg, J.B., Chen, Y., Jiang, N., Beasley, B.E., Salerno, J.C. and Ghosh, D.K. 2009 Inhibition of nitric oxide synthase by cobalamins and cobinamides. Free Radic Biol Med. 46, 1626-1632.

  6. Zheng, D. and Birke, R.L. 2001 Spectroscopic evidence for nitric oxide binding with cob(II)alamin. JAm Chem Soc. 123, 4637-8

  7. Zheng, D. and Birke, R.L. 2002 The reaction of nitric oxide with glutathionylcobalamin. J Am Chem Soc 124, 9066-7

Vitamin B12 and Chronic Pain

  1. Hosseinzadeh H, Moallem SA, Moshiri M, Sarnavazi MS, Etemad L. Anti-nociceptive and Anti-inflammatory Effects of Cyanocobalamin (Vitamin B12) Against Acute and Chronic Pain and Inflammation in Mice. Arzneimittelforschung. 2012 Jul;62(7):324-9.

  2. Chiu CK, Low TH, Tey YS, Singh VA, Shong HK. The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial. Singapore Med J. 2011 Dec;52(12):868-73.

  3. Caram-Salas NL, Reyes-García G, Medina-Santillán R, Granados-Soto V. Thiamine and cyanocobalamin relieve neuropathic pain in rats: synergy with dexamethasone. Pharmacology 2006; 77:53-62.

  4. Wang ZB, Gan Q, Rupert RL, Zeng YM, Song XJ. Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain 2005; 114:266-77.

  5. Granados-Soto V, Sánchez-Ramirez G, la Torre MR, et al. Effect of diclofenac on the antiallodynic activity of vitamin B12 in a neuropathic pain model in the rat. Proc West Pharmacol Soc 2004; 47:92-4.

  6. França DS, Souza AL, Almeida KR, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Phamacol 2001; 421:157-64.

  7. Leuschner J. Antinociceptive properties of thiamine, pyridoxine and cyanocobalamin following repeated oral administration to mice. Arzneimittelforschung 1992; 42:114-5.

  8. Jurna I, Carlsson KH, Kömen W, Bonke D. Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: dose-response relationship and combinations with morphine and paracetamol. Klin Wochenschr 1990; 68:129-35.

  9. Rocha-González HI, Terán-Rosales F, Reyes-García G, Medina-Santillán R, Granados-Soto V. B vitamins increase the analgesic effect of diclofenac in the rat. Proc West Pharmacol Soc 2004; 47:84-7.

  10. Reyes-García G, Medina-Santillán R, Terán-Rosales F, et al. B vitamins increase the anti-hyperalgesic effect of diclofenac in the rat. Proc West Pharmacol Soc 2002; 45:147-9.

  11. Reyes-García G, Medina-Santillán R, Terán-Rosales F, Mateos-García E, Castillo-Henkel C. Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat. J Pharmacol Toxicol Methods 1999; 42:73-7.

  12. Bartoszyk GD, Wild A. B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test. Neurosci Lett 1989; 101:95-100.

  13. Brüggemann G, Koehler CO, Koch EM. [Results of a doubleblind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. Klin Wochenschr 1990; 68:116-20. German.

  14. Kuhlwein A, Meyer HJ, Koehler CO. [Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes]. Klin Wochenschr 1990; 68:107-15. German.

  15. Vetter G, Brüggemann G, Lettko M, et al. [Shortening diclofenac therapy by B vitamins. Results of a randomized doubleblind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes]. Z Rheumatol 1988; 47:351-62. German.

  16. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 2005; 14:48-54.

  17. Kuwabara S, Nakazawa R, Azuma N, et al. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999; 38:472-5.

  18. Li G. [Effect of mecobalamin on diabetic neuropathies. Beijing Methycobal Clinical Trial Collaborative Group]. Zhonghua Nei Ke Za Zhi 1999; 38:14-7. Chinese.

  19. Waikakul W, Waikakul S. Methylcobalamin as an adjuvant medication in conservative treatment of lumbar spinal stenosis. J Med Assoc Thai 2000; 83:825-31

Vitamin B12 and Eczema

  1. Januchowski R. Evaluation of topical vitamin B(12) for the treatment of childhood eczema. J Altern Complement Med. 2009 Apr;15(4):387-9.

  2.  Jung SH, Cho YS, Jun SS, Koo JS, Cheon HG, Shin BC. Topical application of liposomal cobalamin hydrogel for atopic dermatitis therapy. Pharmazie. 2011 Jun;66(6):430-5.

  3.  Stücker M, Pieck C, Stoerb C, Niedner R, Hartung J, Altmeyer P. Topical vitamin B12--a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Br J Dermatol. 2004 May;150(5):977-83.

Vitamin B12 in the Treatment of Diabetic Neuropathy

  1. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 2005; 14:48-54.

  2. Kuwabara S, Nakazawa R, Azuma N, et al. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999; 38:472-5.

  3. Li G. [Effect of mecobalamin on diabetic neuropathies. Beijing Methycobal Clinical Trial Collaborative Group]. Zhonghua Nei Ke Za Zhi 1999; 38:14-7. Chinese.

  4. Jianbo L, Yuche C, Ming S, Jingrong T, Qing D, Yu Z, Jiawei C, Hongxing W. Association of homocysteine with peripheral neuropathy in Chinese patients with type 2 diabetes. Diabetes Res Clin Pract. 2011 Apr 8. [Epub ahead of print]

  5. Jian-bo L, Cheng-ya W, Jia-wei C, Xiao-lu L, Zhen-qing F, Hong-tai M. The preventive efficacy of methylcobalamin on rat peripheral neuropathy influenced by diabetes via neural IGF-1 levels.Nutr Neurosci. 2010 Apr;13(2):79-86.

  6. Bell DS. Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. South Med J. 2010 103(3):265-7.

  7. Freeman R. Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy. Curr Diab Rep. 2009 Dec;9(6):423-31. Review.

  8. Wile DJ, Toth C. Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. Diabetes Care. 2010 Jan;33(1):156-61. Epub 2009 Oct 21.

  9. Ukinc K, Ersoz HO, Karahan C, Erem C, Eminagaoglu S, Hacihasanoglu AB, Yilmaz M, Kocak M. Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy. Endocrine. 2009 Oct;36(2):255-61. Epub 2009 Jul 14.

  10. Jolivalt CG, Mizisin LM, Nelson A, Cunha JM, Ramos KM, Bonke D, Calcutt NA. B vitamins alleviate indices of neuropathic pain in diabetic rats. Eur J Pharmacol. 2009 Jun 10;612(1-3):41-7. Epub 2009 Apr 23.

  11. Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr. 2009;60 Suppl 5:71-6. Epub 2009 Feb 11.

  12. Zhang YF, Ning G. Mecobalamin. Expert Opin Investig Drugs. 2008 Jun;17(6):953-64. Review.

  13. Gorson KC, Ropper AH. Additional causes for distal sensory polyneuropathy in diabetic patients. J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):354-8.

  14. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005 Jun;14(2):48-54. Review.

  15. de Luis DA, Fernandez N, Arranz ML, Aller R, Izaola O, Romero E. Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2. J Diabetes Complications. 2005 Jan-Feb;19(1):42-6.

  16. Beitzke M, Pfister P, Fortin J, Skrabal F. Autonomic dysfunction and hemodynamics in vitamin B12 deficiency. Auton Neurosci. 2002 Apr 18;97(1):45-54.

  17. Ambrosch A, Dierkes J, Lobmann R, Kühne W, König W, Luley C, Lehnert H. Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus. Diabet Med. 2001 Mar;18(3):185-92.

  18. Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med. 1999 Jun;38(6):472-5.

  19. Yaqub BA, Siddique A, Sulimani R. Effects of methylcobalamin on diabetic neuropathy. Clin Neurol Neurosurg. 1992;94(2):105-11.

  20. Ide H, Fujiya S, Asanuma Y, Tsuji M, Sakai H, Agishi Y. Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy. Clin Ther. 1987;9(2):183-92.

  21. Taniguchi H, Ejiri K, Baba S. Improvement of autonomic neuropathy after mecobalamin treatment in uremic patients on hemodialysis. Clin Ther. 1987;9(6):607-14.

  22. Tashiro S, Sudou K, Imoh A, Koide M, Akazawa Y. Phosphatidylethanolamine methyltransferase activity in developing, demyelinating, and diabetic mouse brain. Tohoku J Exp Med. 1983 Dec;141 Suppl:485-90.

  23. Yagihashi S, Tokui A, Kashiwamura H, Takagi S, Imamura K. In vivo effect of methylcobalamin on the peripheral nerve structure in streptozotocin diabetic rats. Horm Metab Res. 1982 Jan;14(1):10-3.