Vitamin B12 Deficiency: What are the consequences?

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Scientific publications Vitamin B12 Deficiency and Neuritis

  1. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 2005; 14:48-54.

  2. Kuwabara S, Nakazawa R, Azuma N, et al. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999; 38:472-5.

  3. Li G. [Effect of mecobalamin on diabetic neuropathies. Beijing Methycobal Clinical Trial Collaborative Group]. Zhonghua Nei Ke Za Zhi 1999; 38:14-7. Chinese.

  4. Jianbo L, Yuche C, Ming S, Jingrong T, Qing D, Yu Z, Jiawei C, Hongxing W. Association of homocysteine with peripheral neuropathy in Chinese patients with type 2 diabetes. Diabetes Res Clin Pract. 2011 Apr 8. [Epub ahead of print]

  5. Jian-bo L, Cheng-ya W, Jia-wei C, Xiao-lu L, Zhen-qing F, Hong-tai M. The preventive efficacy of methylcobalamin on rat peripheral neuropathy influenced by diabetes via neural IGF-1 levels.Nutr Neurosci. 2010 Apr;13(2):79-86.

  6. Bell DS. Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. South Med J. 2010 Mar;103(3):265-7.

  7. Freeman R. Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy. Curr Diab Rep. 2009 Dec;9(6):423-31. Review.

  8. Wile DJ, Toth C. Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. Diabetes Care. 2010 Jan;33(1):156-61. Epub 2009 Oct 21.

  9. Ukinc K, Ersoz HO, Karahan C, Erem C, Eminagaoglu S, Hacihasanoglu AB, Yilmaz M, Kocak M. Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy. Endocrine. 2009 Oct;36(2):255-61. Epub 2009 Jul 14.

  10. Jolivalt CG, Mizisin LM, Nelson A, Cunha JM, Ramos KM, Bonke D, Calcutt NA. B vitamins alleviate indices of neuropathic pain in diabetic rats. Eur J Pharmacol. 2009 Jun 10;612(1-3):41-7. Epub 2009 Apr 23.

  11. Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr. 2009;60 Suppl 5:71-6. Epub 2009 Feb 11.

  12. Zhang YF, Ning G. Mecobalamin. Expert Opin Investig Drugs. 2008 Jun;17(6):953-64. Review.

  13. Gorson KC, Ropper AH. Additional causes for distal sensory polyneuropathy in diabetic patients. J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):354-8.

  14. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005 Jun;14(2):48-54. Review.

  15. de Luis DA, Fernandez N, Arranz ML, Aller R, Izaola O, Romero E. Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2. J Diabetes Complications. 2005 Jan-Feb;19(1):42-6.

  16.  Beitzke M, Pfister P, Fortin J, Skrabal F. Autonomic dysfunction and hemodynamics in vitamin B12 deficiency. Auton Neurosci. 2002 Apr 18;97(1):45-54.

  17.  Ambrosch A, Dierkes J, Lobmann R, Kühne W, König W, Luley C, Lehnert H. Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus. Diabet Med. 2001 Mar;18(3):185-92.

  18.  Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med. 1999 Jun;38(6):472-5.

  19. Yaqub BA, Siddique A, Sulimani R. Effects of methylcobalamin on diabetic neuropathy. Clin Neurol Neurosurg. 1992;94(2):105-11.

  20.  Ide H, Fujiya S, Asanuma Y, Tsuji M, Sakai H, Agishi Y. Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy. Clin Ther. 1987;9(2):183-92.

  21. Taniguchi H, Ejiri K, Baba S. Improvement of autonomic neuropathy after mecobalamin treatment in uremic patients on hemodialysis. Clin Ther. 1987;9(6):607-14.

  22. Tashiro S, Sudou K, Imoh A, Koide M, Akazawa Y. Phosphatidylethanolamine methyltransferase activity in developing, demyelinating, and diabetic mouse brain. Tohoku J Exp Med. 1983 Dec;141 Suppl:485-90.

  23. Yagihashi S, Tokui A, Kashiwamura H, Takagi S, Imamura K. In vivo effect of methylcobalamin on the peripheral nerve structure in streptozotocin diabetic rats. Horm Metab Res. 1982 Jan;14(1):10-3.

Vitamin B12 deficiency and Neuronal conditions

  1. Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 1988;318:1720–8. [PubMed]

  2. Richard A Rison, Said R Beydoun Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature J Med Case Reports. 2010; 4: 298. Published online 2010 September 1. doi: 10.1186/1752-1947-4-298

  3. Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 1988;318:1720–8. [PubMed]

  4. Chang-E Zhang, Wei Wei, Ying-Hua Liu, Jun-Hua Peng, Qing Tian, Gong-Ping Liu, Yao Zhang, Jian-Zhi WangHyperhomocysteinemia Increases β-Amyloid by Enhancing Expression of γ-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain Am J Pathol. 2009 April; 174(4): 1481–1491.

  5. Elke Voss, Peter Raab, Corinna Trebst, Martin Stangel Clinical approach to optic neuritis: pitfalls, red flags and differential diagnosis Ther Adv Neurol Disord. 2011 March; 4(2): 123–134. doi: 10.1177/1756285611398702

  6. N. H. Wadia, M. M. Desai, E. V. Quadros, D. K. Dastur Role of Vegetarianism, Smoking, and Hydroxocobalamin in Optic Neuritis Br Med J. 1972 July 29; 3(5821): 264–267.

  7. Emmanuel Andrès, Noureddine Henoun Loukili, Esther Noel, Georges Kaltenbach, Maher Ben Abdelgheni, Anne Elisabeth Perrin, Marie Noblet-Dick, Frédéric Maloisel, Jean-Louis Schlienger, Jean-Frédéric BlickléVitamin B12 (cobalamin) deficiency in elderly patients CMAJ. 2004 August 3; 171(3): 251–259. doi: 10.1503/cmaj.1031155

  8. A. D. M. Smith Br Med J. Veganism: A Clinical Survey with Observations on Vitamin-B12 Metabolism 1962 June 16; 1(5293): 1655–1658.

  9. Laura M Nightingale, Dominic C Paviour Nutritional optic and peripheral neuropathy: a case report Cases J. 2009; 2: 7762. Published online 2009 June 5. doi: 10.4076/1757-1626-2-7762

  10. Angel P Sempere, ML Tahoces, Susana Palao-Duarte, Alfonso Garcia-Perez Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report  J Med Case Reports. 2011; 5: 319. Published online 2011 July 19. doi: 10.1186/1752-1947-5-319

  11. W. J. Makene, J. Wilson Biochemical studies in Tanzanian patients with ataxic tropical neuropathy J Neurol Neurosurg Psychiatry. 1972 February; 35(1): 31–33.

  12.  M. G. Whiteside, D. L. Mollin, N. F. Coghill, A. Wynn Williams, Barbara Anderson The absorption of radioactive vitamin B12 and the secretion of hydrochloric acid in patients with atrophic gastritis Gut. 1964 October; 5(5): 385–399.

  13.  Aidan Redmond Efficacy of Vitamin B12 in the Alleviation of the Lightning Pains of Tabes Dorsalis Br J Vener Dis. 1957 June; 33(2): 118–119.

  14.  Arrigo Vittorio Barabino, Paolo Gandullia, Angela Calvi, Silvia Vignola, Serena Arrigo, Riccardo De Marco Sudden blindness in a child with Crohn’s disease  World J Gastroenterol. 2011 October 14; 17(38): 4344–4346. Published online 2011 October 14. doi: 10.3748/wjg.v17.i38.4344

  15. Hugh J Freeman Neurological disorders in adult celiac disease  Can J Gastroenterol. 2008 November; 22(11): 909–911.

  16. A G Freeman Cyanocobalamin--a case for withdrawal: discussion paper. J R Soc Med. 1992 November; 85(11): 686–687.

  17. Christopher H Gibbons, Roy Freeman Treatment induced diabetic neuropathy– a reversible painful autonomic neuropathy Ann Neurol. Author manuscript; available in PMC 2011 April 1.

  18. William Alan Nicol Non-Addisonian Megaloblastic Anaemia, Complicated by Subacute Combined Degeneration of the Cord Br Med J. 1960 January 30; 1(5169): 322–324.

  19. J. MacDonald Holmes Cerebral Manifestations of Vitamin-B12 Deficiency Br Med J. 1956 December 15; 2(5006): 1394–1398.

Further Information on Neuritis, Peripheral Neuropathy and Vitamin B12

Check out the following sites for further information:

http://www.livestrong.com/article/291509-peripheral-neuropathy-and-vitamin-b12/

http://peripheralneuropathycenter.uchicago.edu/learnaboutpn/typesofpn/systemic/nutrition.shtml

http://diabetes.webmd.com/news/20090608/metformin-linked-to-b12-deficiency